RESUMO
A Dieulafoy lesion is a relatively rare, but potentially life threatening cause of gastrointestinal bleeding, which accounts for only 1~2% of acute cases. The most common site is the stomach and most extragastric lesions are frequently found in the duodenum followed by the esophagus, the colon, and rectum. However, jejunum and ileum are extremely rare. I report on a case of a 38-year-old female who underwent laparoscopic resection of a bleeding Dieulafoy's lesion in the jejunum following intraoperative endoscopy.
Assuntos
Adulto , Feminino , Humanos , Colo , Duodeno , Endoscopia , Esôfago , Hemorragia , Íleo , Jejuno , Reto , EstômagoRESUMO
OBJECTIVES: The molecular mechanisms that regulate cardiomyocyte cell cycle and terminal differentiation in humans remain largely unknown. To determine which cyclins, cyclin dependent kinases (CDKs) and cyclin kinase inhibitors (CKIs) are important for cardiomyocyte proliferation, we have examined protein levels of cyclins, CDKs and CKIs during normal atrial development in humans. METHODS: Atrial tissues were obtained in the fetus from inevitable abortion and in the adult during surgery. Cyclin and CDK proteins were determined by Western blot analysis. CDK activities were determined by phosphorylation amount using specific substrate. RESULTS: Most cyclins and CDKs were high during the fetal period and their levels decreased at different rates during the adult period. While the protein levels of cyclin D1, cyclin D3, CDK4, CDK6 and CDK2 were still detectable in adult atria, the protein levels of cyclin E, cyclin A, cyclin B, cdc2 and PCNA were not detectable. Interestingly, p27KIP1 protein increased markedly in the adult period, while p21CIP1 protein in atria was detectable only in the fetal period. While the activities of CDK6, CDK2 and cdc2 decreased markedly, the activity of CDK4 did not change from the fetal period to the adult period. CONCLUSION: These findings indicate that marked reduction of protein levels and activities of cyclins and CDKs, and marked induction of p27KIP1 in atria, are associated with the withdrawal of cardiac cell cycle in adult humans.
Assuntos
Adulto , Feminino , Humanos , Masculino , Ratos , Fatores Etários , Animais , Western Blotting , Ciclo Celular , Células Cultivadas , Estudo Comparativo , Ciclina A/análise , Ciclina B/análise , Ciclina D1/análise , Ciclina E/análise , Quinases Ciclina-Dependentes/análise , Ciclinas/análise , Desenvolvimento Fetal , Átrios do Coração/crescimento & desenvolvimento , Átrios do Coração/embriologia , Átrios do Coração/citologia , Átrios do Coração/química , Pessoa de Meia-Idade , Miocárdio/química , Ratos Sprague-DawleyRESUMO
Bronchial atresia coexistent with intralobar pulmonary sequestration is so rare that only two cases have been reported in the literature. We report a case of congential bronchial atresia coexistent with intralobar pulmonary sequestation in a 51 year-old woman. Computed tomography showed the branching mass with hyperinflation of adjacent pulmonary parenchyma in the medial segment of the right middle lobe and a large thin-walled cystic mass with air-fluid levels in the medial basal segment of the right lower lobe. Selective inferior phrenic arteriography showed two aberrant arteries supplying the large cystic mass in the right lower lobe. The venous drainage was through the right pulmonary vein.
Assuntos
Feminino , Humanos , Pessoa de Meia-Idade , Angiografia , Artérias , Sequestro Broncopulmonar , Drenagem , Veias PulmonaresRESUMO
This report describes a sclerosing hemangioma of the lung evaluated by MRI. The mass demonstrated hyperintense signal on T1 -weighted, proton density, and T2-weighted spin-echo images. Contrast-enhanced T1 -weighted images showed marked, homogeneous enhancement of the mass. The MR appearance is not specific for sclerosing hemangioma of the lung, as other benign tumors can appear similarly. However, the appearance of homogeneous enhancement within the mass on Gd-DTPA enhanced MR may suggest the diagnosis.
Assuntos
Diagnóstico , Gadolínio DTPA , Histiocitoma Fibroso Benigno , Imageamento por Ressonância Magnética , Prótons , Hemangioma Esclerosante PulmonarRESUMO
This report describes a sclerosing hemangioma of the lung evaluated by MRI. The mass demonstrated hyperintense signal on T1 -weighted, proton density, and T2-weighted spin-echo images. Contrast-enhanced T1 -weighted images showed marked, homogeneous enhancement of the mass. The MR appearance is not specific for sclerosing hemangioma of the lung, as other benign tumors can appear similarly. However, the appearance of homogeneous enhancement within the mass on Gd-DTPA enhanced MR may suggest the diagnosis.
Assuntos
Diagnóstico , Gadolínio DTPA , Histiocitoma Fibroso Benigno , Imageamento por Ressonância Magnética , Prótons , Hemangioma Esclerosante PulmonarRESUMO
No abstract available.